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Lewy body variant of Alzheimer's disease (AD)
A form of AD characterized by the presence of Lewy bodies & Hirano bodies. Amyloid plaques are present in the usual abundance (in contrast to diffuse Lewy body disease); however, neurofibrillary tangles are few in number.
It is considered by some to be one & the same as diffuse Lewy body disease (Lewy body dementia) [1]. Others [2] consider it a separate entity.
Interactions
disease interactions
Related
Lewy body dementia
General
Alzheimer's disease (AD)
synucleinopathy (includes alpha-synucleinopathy)
Properties
PATHOLOGY: neurofibrillary tangle
amyloid plaque
cerebral amyloid angiopathy
granulovacuolar change
Hirano body
Lewy body
References
- Bruce Miller, M.D., UCSF Memory & Aging Center, 2001
- Selkoe DJ.
Alzheimer's disease: genes, proteins, and therapy.
Physiol Rev. 2001 Apr;81(2):741-66. Review.
PMID: 11274343